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Year : 2023  |  Volume : 8  |  Issue : 1  |  Page : 30-33

Relationship between serum IgE level and childhood nephrotic syndrome with atypical presentation

1 Department of Pediatrics, Chittagong Medical College Hospital, Chattogram, Bangladesh
2 Department of Pediatric Nephrology, Chittagong Medical College Hospital, Chattogram, Bangladesh

Correspondence Address:
Dr. Munmun Chowdhury
Research Assistant, Department of Pediatrics, Chittagong Medical College Hospital, Chattogram 4203
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pnjb.pnjb_27_22

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Background: Patients with nephrotic syndrome (NS) have altered serum immunoglobulin E (IgE) levels during relapse and remission, while presentation may be typical or atypical. Objective: To evaluate serum IgE level in childhood NS with the atypical and typical presentation. Materials and Methods: A total of 66 children with NS aged between 1 and 12 years were enrolled in this cross-sectional study. Among them, 33 children were with atypical presentations, and an equal number of children were with the typical presentations. Serum IgE level was measured in all cases. Result: The mean age of patients was 5.9 ± 3.1 years with a male-to-female ratio of 1.4:1. The mean serum IgE level was 1063.2 ± 1042.6 IU/mL in NS atypical presentation and 1099.8 ± 842.1 IU/mL in NS typical presentation, both of which were higher than the normal range for age but statistically not significant (P = 0.877). Conclusion: Elevated level of serum IgE is a feature of childhood NS with atypical and typical presentations.

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