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ORIGINAL ARTICLE
Year : 2022  |  Volume : 7  |  Issue : 2  |  Page : 58-62

Renal function assessment by estimation of fractional excretion of sodium and magnesium in asphyxiated newborn


1 Department of Pediatric Nephrology, Chittagong Medical College, Chittagong, Bangladesh
2 Department of Pediatric Nephrology, Dhaka Shishu (Children) Hospital, Sher-e-Banglanagar, Dhaka, Bangladesh
3 Department of Pediatric Nephrology, National Institute of Kidney Diseases and Urology, Sher-e-Banglanagar, Dhaka, Bangladesh

Correspondence Address:
Dr. Mohammed Maruf Ul Quader
Department of Pediatric Nephrology, Chittagong Medical College, 57 KB Fazlul Kader Road, Chittagong 4203
Bangladesh
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pnjb.pnjb_2_22

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Background: Fractional excretion of magnesium (FEMg) is found to be the most sensitive index among fractional excretion of solutes to detect tubular damage in glomerulonephritis, although fractional excretion of sodium (FENa) is used to detect renal tubular dysfunction in perinatal asphyxia till date. Aim and Objective: The aim of this article is to assess the diagnostic performance of FENa and FEMg as renal function test in asphyxiated newborns. Materials and Methods: This cross-sectional study was conducted on 100 asphyxiated newborns in Dhaka Shishu (Children) Hospital, Bangladesh, over 1 year. Serum and urine creatinine, sodium, and magnesium were assessed in each patient; FENa and FEMg were calculated. Serum creatinine was regarded as gold standard for renal function. Results: FENa had 63.64% sensitivity, 100% specificity, 100% positive predictive value, 90.70% negative predictive value, and 92% accuracy. FEMg had 100% sensitivity, 66.67% specificity, 45.83% positive predictive value, 100% negative predictive value, and 74% accuracy. Receiver-operating characteristic curve revealed that area under the curve for FENa was 0.990 and for FEMg was 0.833. So, area under the curve for FENa was more than that of FEMg. Conclusion: FENa is better than FEMg in the assessment of renal function of asphyxiated newborns.


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