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Year : 2022  |  Volume : 7  |  Issue : 1  |  Page : 34-36

Henoch–Schönlein purpura: Simultaneous occurrence in two siblings—Case reports

1 Department of Pediatrics, Chittagong Medical College, Chattogram, Bangladesh
2 Department of Skin and VD, Chittagong Medical College, Chattogram, Bangladesh
3 Department of Pediatric Nephrology, Chittagong Medical College, Chattogram, Bangladesh

Correspondence Address:
Dr. Mohammed Maruf-Ul- Quader
Department of Pediatric Nephrology, Chittagong Medical College, Chattogram
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pnjb.pnjb_1_22

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Henoch–Schönlein purpura (HSP) is one of the most common vasculitis in children. Typically, HSP is considered to be self-limiting, although renal involvement (HSP nephritis) is the principal cause of morbidity from this disease. Familial cases of this disease are not common. Only a few cases have been reported. A 7-year-old girl presented with a history of (H/O) abdominal pain, arthritis, and purpuric rash on lower extremities. Laboratory investigations revealed hematuria, proteinuria, and thrombocytosis with a normal IgA level. Renal biopsy revealed mesangial and focal endocapillary proliferative glomerular morphology with partial cellular crescent. Two weeks later, a sister of the first case presented with palpable purpura without any arthritis or nephritis. In both the cases, there was no H/O any upper respiratory tract infection or atopy. Herein, we speculated that the environmental factors may be responsible for the simultaneous occurrence of HSP in a genetically susceptible environment.

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