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Year : 2022  |  Volume : 7  |  Issue : 1  |  Page : 29-33

Case-based management of nephrotic syndrome: A review and update

Department of Pediatric Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

Correspondence Address:
Prof. Golam M Uddin
Department of Pediatric Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pnjb.pnjb_8_22

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Nephrotic syndrome (NS) is one of the most common glomerular diseases that affect children. The most common cause of NS is idiopathic NS (INS). Minimal change NS (MCMS) is more than 80% in patients with favorable outcomes. However, a few children have focal segmental glomerulosclerosis along with secondary causes, which are at risk for complications. Complications may be disease-associated or may be drug-related complications. Disease-related complications include infections (e.g., peritonitis, sepsis, cellulitis, chicken pox), thrombo-embolism, hypovolemic crisis, hypercholesterolemia, acute kidney injury (AKI), anemia and other AKIs, hypothyroidism, hypocalcemia, and bone disease. The majority of children with MCNS respond to corticosteroids or cytotoxic agents, alkylating agents, cyclosporine A, and mycophenolate mofetil. Early detection and management of these complications will improve outcome for these patients with NS. This article provides an update of current available therapeutics strategies and case-based management of common complications of NS.

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